Tryptophan Metabolism and Gut Microbiota

Gut Microbiota and Neuropsychiatric Disorders

Gut microbiota, enteroendocrine functions and metabolism.

The gut microbiota affects host metabolism through a number of physiological processes. Emerging evidence suggests that gut microbes interact with the host through several pathways involving enteroendocrine cells (e.g. L cells). The activation of specific G protein coupled receptors expressed on L cells (e.g. GPR41, GPR43, GPR119 and TGR5) triggers the secretion of glucagon-like peptides (GLP-1...

Psychobiotics and Brain-Gut Microbiota Axis

Fermented foods containing probiotic bacteria have been used for many years to improve the health or treatment of some diseases. Nowadays, the Therapeutic properties of probiotics are becoming more and more obvious to everyone, insofar as in recent years, more attention has been paid to the potential relation between gut microbiota and mental health. Several studies have shown that intestinal m...

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between intestinal immune tolerance and gut microbiota maintenance. Recent discoveries have underscored that changes in the microbiota modulate the host immu...

Interaction between Intestinal Microbiota and Serotonin Metabolism

Gut microbiota regulates the production of signaling molecules, such as serotonin or 5-Hydroxytryptamine: 5-HT in the host. Serotonin is a biogenic amine that acts as a neurotransmitter in the gut and brain. There is a perfect interaction between human gastrointestinal microbiota and the serotonin system. The gut microbiota plays an important role in the serotonin signaling pathways through the...